Received: JAccepted: NovemPublished: December 7, 2020Д¬opyright: В© 2020 Dorjee et al. PLoS ONE 15(12):Д®ditor: Davide Bolignano, Universita degli Studi Magna Graecia di Catanzaro, ITALY The prevalence of hypertension (55%), diabetes (33%), smoking history (23%) and heart disease (17%) among the COVID-19 hospitalized patients in the US were substantially higher than that of the general US population, suggesting increased susceptibility to infection or disease progression for the individuals with comorbidities.Д¬itation: Dorjee K, Kim H, Bonomo E, Dolma R (2020) Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients. Summary relative risk (sRR) of death were higher for ageв‰Ґ60 years, males, smoking history, COPD, hypertension, diabetes, heart disease, CKD. The case fatality risk were 52% (46вЂ“60) for heart disease, 51% (43вЂ“59) for COPD, 48% (37вЂ“63) for chronic kidney disease (CKD), 39% for chronic liver disease (CLD), 28% (23вЂ“36%) for hypertension, and 24% (17вЂ“33%) for diabetes. Of those that died, 85% were agedв‰Ґ60 years, 66% were males, and 66%, 44%, 39%, 37%, and 27% had hypertension, smoking history, diabetes, heart disease, and chronic kidney disease (CKD), respectively. Overall prevalence of death from COVID-19 was 20% (18вЂ“23%) 23% (19вЂ“27%) in the US and Europe and 11% (7вЂ“16%) for China.

Seventy-seven studies comprising 38906 hospitalized patients met inclusion criteria 21468 from the US-Europe and 9740 from China.

Comprehensive meta analysis chapter 19